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Antimicrobial Agents and Chemotherapy, December 2007, p. 4495-4497, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00753-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pyrrolidine Dithiocarbamate and Diethyldithiocarbamate Are Active against Growing and Nongrowing Persister Mycobacterium tuberculosis

Sean T. Byrne,^1, Peihua Gu,^1, Jiangbing Zhou,¹ Steven M. Denkin,¹ Curtis Chong,² David Sullivan,¹ Jun O. Liu,² and Ying Zhang^1*

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, Maryland 21205,¹ Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N. Wolfe St., Baltimore, Maryland 21205²

Received 11 June 2007/ Returned for modification 6 July 2007/ Accepted 5 September 2007

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 µg/ml and 0.13 µg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

Published ahead of print on 17 September 2007.

These authors contributed equally.