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Antimicrobial Agents and Chemotherapy, December 2007, p. 4502-4504, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00933-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Time of Incubation for Antifungal Susceptibility Testing of Aspergillus fumigatus: Can MIC Values Be Obtained at 24 Hours?{triangledown}

Juan Luis Rodriguez-Tudela,* Laura Alcazar-Fuoli, Ana Alastruey-Izquierdo, Araceli Monzon, Emilia Mellado, and Manuel Cuenca-Estrella

Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain

Received 19 July 2007/ Returned for modification 6 September 2007/ Accepted 2 October 2007

A collection of Aspergillus fumigatus isolates was used to check if MICs can be read at 24 h. At 24 h, the geometric mean MIC of itraconazole for resistant isolates was determined to be 5.11 mg/liter, but the MIC was read as 16 mg/liter at 48 h. At 24 h, MICs for 51.5% of resistant strains were determined to be ≤2 mg/liter. MICs must be obtained at 48 h.

* Corresponding author. Mailing address: Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Spain. Phone: 34 91 822 3919. Fax: 34 91 509 7966. E-mail: jlrtudela{at}isciii.es

{triangledown} Published ahead of print on 15 October 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4502-4504, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00933-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Alastruey-Izquierdo, A., Castelli, M. V., Cuesta, I., Monzon, A., Cuenca-Estrella, M., Rodriguez-Tudela, J. L. (2009). Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers. Antimicrob. Agents Chemother. 53: 1686-1689 [Abstract] [Full Text]  
  • Rodriguez-Tudela, J. L., Alcazar-Fuoli, L., Mellado, E., Alastruey-Izquierdo, A., Monzon, A., Cuenca-Estrella, M. (2008). Epidemiological Cutoffs and Cross-Resistance to Azole Drugs in Aspergillus fumigatus. Antimicrob. Agents Chemother. 52: 2468-2472 [Abstract] [Full Text]  
  • Garcia-Effron, G., Dilger, A., Alcazar-Fuoli, L., Park, S., Mellado, E., Perlin, D. S. (2008). Rapid Detection of Triazole Antifungal Resistance in Aspergillus fumigatus. J. Clin. Microbiol. 46: 1200-1206 [Abstract] [Full Text]  


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