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Antimicrobial Agents and Chemotherapy, December 2007, p. 4518-4520, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00808-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

RNAIII-Inhibiting Peptide Affects Biofilm Formation in a Rat Model of Staphylococcal Ureteral Stent Infection{triangledown}

Oscar Cirioni,1* Roberto Ghiselli,2 Daniele Minardi,3 Fiorenza Orlando,4 Federico Mocchegiani,2 Carmela Silvestri,1 Giovanni Muzzonigro,1 Vittorio Saba,2 Giorgio Scalise,1 Naomi Balaban,5 and Andrea Giacometti1

Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy,1 Department of General Surgery, I.N.R.C.A.-I.R.R.C.S., Polytechnic University of the Marche Region, Ancona, Italy,2 Institute of Maternal and Children's Sciences—Urology, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy,3 Experimental Animal Models for Aging Units, Research Department, I.N.R.C.A.-I.R.R.C.S., Ancona, Italy,4 Tufts University, Cummings School of Veterinary Medicine, Department of Biomedical Sciences, North Grafton, Massachusetts 015365

Received 22 June 2007/ Returned for modification 17 August 2007/ Accepted 6 September 2007

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

* Corresponding author. Mailing address: Clinica delle Malattie Infettive, c/o Ospedale Regionale, Via Conca, 71, 60200 Ancona AN, Italy. Phone: 39 071 5963715. Fax: 39 071 5963468. E-mail: anconacmi{at}interfree.it

{triangledown} Published ahead of print on 17 September 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4518-4520, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00808-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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