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Antimicrobial Agents and Chemotherapy, February 2007, p. 740-743, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.00719-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Tolerance to the Glycopeptides Vancomycin and Teicoplanin in Coagulase-Negative Staphylococci{triangledown}

Ingrid Bourgeois, Martine Pestel-Caron,* Jean-Francois Lemeland, Jean-Louis Pons, and Francois Caron

Groupe de Recherche sur les Antimicrobiens et les Microorganismes (U.P.R.E.S. EA 2656, I.F.R. 23), Université de Rouen, U.F.R. Médecine-Pharmacie, F-76183 Rouen, France, and Centre Hospitalier Universitaire, F-76031 Rouen, France

Received 9 June 2006/ Returned for modification 21 August 2006/ Accepted 8 November 2006

Tolerance to vancomycin and teicoplanin in 90 clinical isolates of coagulase-negative staphylococci (CoNS) was investigated by time-kill curve methodology. Only six strains, belonging to the Staphylococcus lugdunensis species, exhibited tolerance. The seven other S. lugdunensis strains tested displayed weak susceptibility to the bactericidal activity of glycopeptides compared to the other CoNS. These phenomena are of concern, since S. lugdunensis is recognized as one of the most pathogenic CoNS.

* Corresponding author. Mailing address: U.F.R. Médecine-Pharmacie de Rouen, G.R.A.M. (EA 2656), 22 Boulevard Gambetta, F-76183 Rouen, France. Phone: (33) 2 35 14 86 54. Fax: (33) 2 32 88 80 24. E-mail: Martine.Pestel-Caron{at}univ-rouen.fr.

{triangledown} Published ahead of print on 20 November 2006.

Antimicrobial Agents and Chemotherapy, February 2007, p. 740-743, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.00719-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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