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Antimicrobial Agents and Chemotherapy, February 2007, p. 755-758, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01360-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole{triangledown}

S. Radhika Prathalingham, Shane R. Wilkinson, David Horn, and John M. Kelly*

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom

Received 31 October 2006/ Returned for modification 10 November 2006/ Accepted 21 November 2006

It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.

* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom. Phone: 44 207 927 2330. Fax: 44 207 636 8739. E-mail: john.kelly{at}lshtm.ac.uk.

{triangledown} Published ahead of print on 4 December 2006.

Antimicrobial Agents and Chemotherapy, February 2007, p. 755-758, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01360-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wilkinson, S. R., Taylor, M. C., Horn, D., Kelly, J. M., Cheeseman, I. (2008). A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc. Natl. Acad. Sci. USA 105: 5022-5027 [Abstract] [Full Text]  


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