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Antimicrobial Agents and Chemotherapy, February 2007, p. 770-773, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01150-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Multistep Resistance Selection and Postantibiotic-Effect Studies of the Antipneumococcal Activity of LBM415 Compared to Other Agents{triangledown}

Klaudia Kosowska-Shick, Kim L. Credito, Glenn A. Pankuch, Bonifacio DeWasse, Pamela McGhee, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 13 September 2006/ Returned for modification 29 October 2006/ Accepted 10 November 2006

LBM415 is a peptide deformylase inhibitor active against gram-positive bacterial species and some gram-negative species. In multiselection studies, LBM415 had low MICs against all Streptococcus pneumoniae strains tested, regardless of their genotype, and selected resistant clones after 14 to 50 days. MIC increases correlated with changes mostly in the 70GXGXAAXQ77 motif in peptide deformylase. The postantibiotic effect of LBM415 ranged from 0.3 to 1.4 h.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

{triangledown} Published ahead of print on 20 November 2006.

Antimicrobial Agents and Chemotherapy, February 2007, p. 770-773, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01150-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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