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Antimicrobial Agents and Chemotherapy, February 2007, p. 777-782, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.00972-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

First Characterization of Fluoroquinolone Resistance in Streptococcus suis{triangledown}

Jose Antonio Escudero,1 Alvaro San Millan,1 Ana Catalan,1 Adela G. de la Campa,2 Estefania Rivero,1 Gema Lopez,1 Lucas Dominguez,1 Miguel Angel Moreno,1 and Bruno Gonzalez-Zorn1*

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain,1 Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain2

Received 4 August 2006/ Returned for modification 23 August 2006/ Accepted 6 November 2006

We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.

* Corresponding author. Mailing address: Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain. Phone: 34 91 3943719. Fax: 34 91 3943908. E-mail: bgzorn{at}vet.ucm.es.

{triangledown} Published ahead of print on 20 November 2006.

Antimicrobial Agents and Chemotherapy, February 2007, p. 777-782, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.00972-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • San Millan, A., Escudero, J. A., Catalan, A., Nieto, S., Farelo, F., Gibert, M., Moreno, M. A., Dominguez, L., Gonzalez-Zorn, B. (2007). {beta}-Lactam Resistance in Haemophilus parasuis Is Mediated by Plasmid pB1000 Bearing blaROB-1. Antimicrob. Agents Chemother. 51: 2260-2264 [Abstract] [Full Text]  


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