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Antimicrobial Agents and Chemotherapy, February 2007, p. 791-793, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01024-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In Vitro{triangledown}

Susanne Perkhofer,* Helene Lugger, Manfred P. Dierich, and Cornelia Lass-Flörl

Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Innsbruck, Austria

Received 16 August 2006/ Returned for modification 6 September 2006/ Accepted 8 November 2006

The MICs and fractional inhibitory concentrations of posaconazole (POS) and voriconazole (VRZ), alone and in combination with amphotericin B (AMB), for the conidia and hyphae of 100 Aspergillus isolates were evaluated. POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%).

* Corresponding author. Mailing address: Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. Phone: 43 512 9003 70729. Fax: 43 512 9003 73700. E-mail: Susanne.Perkhofer{at}i-med.ac.at.

{triangledown} Published ahead of print on 20 November 2006.

Antimicrobial Agents and Chemotherapy, February 2007, p. 791-793, Vol. 51, No. 2
0066-4804/07/$08.00+0     doi:10.1128/AAC.01024-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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