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Antimicrobial Agents and Chemotherapy, March 2007, p. 1078-1081, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01268-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pretreatment with Empty Liposomes Attenuates the Immunopathology of Invasive Pulmonary Aspergillosis in Corticosteroid-Immunosuppressed Mice{triangledown}

Russell E. Lewis,1,2* Georgios Chamilos,1 Randall A. Prince,1,2 and Dimitrios P. Kontoyiannis1,2

College of Pharmacy, University of Houston, Houston, Texas,1 Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas2

Received 10 October 2006/ Returned for modification 30 November 2006/ Accepted 17 December 2006

In a nonneutropenic murine model of invasive pulmonary aspergillosis, pretreatment with empty liposomes (E-lipo) was nearly as effective as 10 mg/kg of body weight liposomal amphotericin B and superior to 1 mg/kg amphotericin B deoxycholate. The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity.

* Corresponding author. Mailing address: Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund St., Houston, TX 77030. Phone: (713) 795-8326. Fax: (713) 795-8383. E-mail: rlewis{at}uh.edu.

{triangledown} Published ahead of print on 28 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1078-1081, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01268-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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