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Antimicrobial Agents and Chemotherapy, March 2007, p. 1085-1088, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00954-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility and Synergy Studies of Burkholderia cepacia Complex Isolated from Patients with Cystic Fibrosis{triangledown}

Juyan Zhou, Yunhua Chen, Setareh Tabibi, Luis Alba, Elizabeth Garber, and Lisa Saiman*

Department of Pediatrics, Columbia University, New York, New York 10032

Received 2 August 2006/ Returned for modification 7 September 2006/ Accepted 30 November 2006

Susceptibility (18 antimicrobial agents including high-dose tobramycin) and checkerboard synergy (23 combinations) studies were performed for 2,621 strains of Burkholderia cepacia complex isolated from 1,257 cystic fibrosis patients. Minocycline, meropenem, and ceftazidime were the most active, inhibiting 38%, 26%, and 23% of strains, respectively. Synergy was rarely noted (range, 1% to 15% of strains per antibiotic combination).

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Pediatrics, Columbia University, College of Physicians & Surgeons, 650 West 168th Street, PH 4 West Room 470, New York, NY 10032. Phone: (212) 305-9446. Fax: (212) 305-9491. E-mail: LS5{at}columbia.edu.

{triangledown} Published ahead of print on 11 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1085-1088, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00954-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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