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Antimicrobial Agents and Chemotherapy, March 2007, p. 1092-1095, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01153-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

High-Level Telithromycin Resistance in a Clinical Isolate of Streptococcus pneumoniae

Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Johannesburg, South Africa,¹ Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada,² Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia³

Received 14 September 2006/ Returned for modification 16 October 2006/ Accepted 26 December 2006

A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a ₆₉GTG₇₁-to-TPS mutation in ribosomal protein L4.

Published ahead of print on 8 January 2007.

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