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Antimicrobial Agents and Chemotherapy, March 2007, p. 1096-1098, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01366-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini{triangledown}

Jennifer Keiser,1* Xiao Shu-Hua,2 Jacques Chollet,1 Marcel Tanner,1 and Jürg Utzinger1

Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland,1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People's Republic of China2

Received 1 November 2006/ Returned for modification 10 December 2006/ Accepted 17 December 2006

We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.

* Corresponding author. Mailing address: Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. Phone: 41 61 284-8218. Fax: 41 61 284-8105. E-mail: jennifer.keiser{at}unibas.ch.

{triangledown} Published ahead of print on 28 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1096-1098, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01366-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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