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Antimicrobial Agents and Chemotherapy, March 2007, p. 1105-1106, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01310-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Cloxyquin (5-Chloroquinolin-8-ol) against Mycobacterium tuberculosis{triangledown}

Poonpilas Hongmanee,1* Kamolchanok Rukseree,2,3 Benjamas Buabut,1 Boontiwa Somsri,1 and Prasit Palittapongarnpim2,3

Department of Pathology, Faculty of Medicine, Ramathibodi Hospital,1 Department of Microbiology, Faculty of Science, Mahidol University, Bangkok,2 National Science and Technology Development Agency, Prathumthani, Thailand3

Received 20 October 2006/ Returned for modification 10 November 2006/ Accepted 8 December 2006

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 µg/ml. The MIC50 and MIC90 were 0.125 and 0.25 µg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.

* Corresponding author. Mailing address: Division of Microbiology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. Phone: 662 02 2011389. Fax: 662 02 3547266. E-mail: Poonpilas{at}hotmail.com.

{triangledown} Published ahead of print on 18 December 2006.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1105-1106, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.01310-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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