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Antimicrobial Agents and Chemotherapy, March 2007, p. 1119-1122, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00779-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Effects of Glutathione and Ascorbic Acid on Streptomycin Sensitivity of Escherichia coli{triangledown}

Manish Goswami, Suhas H. Mangoli, and Narendra Jawali*

Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India

Received 29 June 2006/ Returned for modification 11 August 2006/ Accepted 19 December 2006

We examined the effects of antioxidants and the role of reactive oxygen species (ROS) on the antibacterial action of aminoglycosides in Escherichia coli. We concluded that reduced streptomycin sensitivity in the presence of glutathione and ascorbic acid is not due to the antioxidant-mediated scavenging of ROS.

* Corresponding author. Mailing address: Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. Phone: 91 22-25595078. Fax: 91 22-25505326. E-mail: enjay{at}apsara.barc.gov.in.

{triangledown} Published ahead of print on 8 January 2007.

Antimicrobial Agents and Chemotherapy, March 2007, p. 1119-1122, Vol. 51, No. 3
0066-4804/07/$08.00+0     doi:10.1128/AAC.00779-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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