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Antimicrobial Agents and Chemotherapy, April 2007, p. 1494-1496, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00666-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci{triangledown}

Andrea Giacometti,1* Oscar Cirioni,1 Alessandra Riva,1 Wojciech Kamysz,2 Carmela Silvestri,1 Piotr Nadolski,2 Agnese Della Vittoria,1 Jerzy Lukasiak,2 and Giorgio Scalise1

Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy,1 Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland2

Received 1 June 2006/ Returned for modification 12 November 2006/ Accepted 27 December 2006

This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.

* Corresponding author. Mailing address: Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. Phone: 39-071-5963715. Fax: 39-071-5963468. E-mail: anconacmi{at}interfree.it or a.giacometti{at}univpm.it

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1494-1496, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00666-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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