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Antimicrobial Agents and Chemotherapy, April 2007, p. 1504-1507, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01455-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Activity of Daptomycin Alone and in Combination with Rifampin and Gentamicin against Staphylococcus aureus Assessed by Time-Kill Methodology{triangledown} ,{dagger}

Kim Credito, Gengrong Lin, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 20 November 2006/ Returned for modification 2 January 2007/ Accepted 4 January 2007

The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 µg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 12 January 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1504-1507, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01455-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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