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Antimicrobial Agents and Chemotherapy, April 2007, p. 1508-1511, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01517-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antistaphylococcal Activity of DX-619 Alone and in Combination with Vancomycin, Teicoplanin, and Linezolid Assessed by Time-Kill Synergy Testing{triangledown} ,{dagger}

Kim Credito, Genrong Lin, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033

Received 4 December 2006/ Returned for modification 2 January 2007/ Accepted 17 January 2007

Time-kill synergy studies testing in vitro activity of DX-619 alone and with added vancomycin, teicoplanin, or linezolid against 101 Staphylococcus aureus strains showed synergy between DX-619 and teicoplanin at 12 to 24 h in 72 strains and between DX-619 and vancomycin in 28 strains. No synergy was found with linezolid, and no antagonism was observed with any combination.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 29 January 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1508-1511, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01517-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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