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Antimicrobial Agents and Chemotherapy, April 2007, p. 1520-1523, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01141-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Species-Specific Differences in the Susceptibilities of Biofilms Formed by Candida Bloodstream Isolates to Echinocandin Antifungals{triangledown}

Hyun Woo Choi,1 Jong Hee Shin,1* Sook In Jung,2 Kyung Hwa Park,2 Duck Cho,1 Seung Jung Kee,1 Myung Geun Shin,1 Soon Pal Suh,1 and Dong Wook Ryang1

Departments of Laboratory Medicine,1 Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea2

Received 11 September 2006/ Returned for modification 26 October 2006/ Accepted 28 January 2007

The echinocandin susceptibilities of bloodstream Candida isolates growing in a biofilm was investigated. Within the therapeutic range of concentrations of each drug, caspofungin and micafungin were active against biofilms formed by Candida albicans or C. glabrata but not those formed by C. tropicalis or C. parapsilosis.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Chonnam National University Medical School, 8 Hakdong Dongku, Gwangju 501-757, South Korea. Phone: 82 (62) 220-5342. Fax: 82 (62) 224-2518. E-mail: shinjh{at}chonnam.ac.kr

{triangledown} Published ahead of print on 5 February 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1520-1523, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01141-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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