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Antimicrobial Agents and Chemotherapy, April 2007, p. 1530-1533, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01132-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genetics and Expression of the Carbapenem-Hydrolyzing Oxacillinase Gene blaOXA-23 in Acinetobacter baumannii{triangledown}

Stéphane Corvec,1,2 Laurent Poirel,1 Thierry Naas,1 Henri Drugeon,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 K Bicêtre,1 Laboratoire de Bactériologie-Virologie, Hygiène Hospitalière, CHU, Nantes, France2

Received 8 September 2006/ Returned for modification 4 November 2006/ Accepted 27 December 2006

The genetic structures surrounding the plasmid-carried blaOXA-23 oxacillinase gene, encoding resistance to carbapenems, were studied in Acinetobacter baumannii. ISAba1 and the novel element ISAba4 were detected upstream of the blaOXA-23 gene, providing promoter sequences for its expression. These insertion elements were likely involved in transposition processes at the origin of acquisition of this ß-lactamase gene.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1530-1533, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01132-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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