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Antimicrobial Agents and Chemotherapy, April 2007, p. 1541-1544, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00999-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Inhibition of Streptococcus mutans Biofilm Formation on Hydroxyapatite by Subinhibitory Concentrations of Anthraquinones{triangledown}

Tom Coenye,1* Kris Honraet,1,2 Petra Rigole,1,2 Pol Nadal Jimenez,1 and Hans J. Nelis1

Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Gent,1 Oystershell NV, Drongen, Belgium2

Received 10 August 2006/ Returned for modification 23 October 2006/ Accepted 20 November 2006

We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by causing membrane perturbation.

* Corresponding author. Mailing address: Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium. Phone: 32 9 2648093. Fax: 32 9 2648195. E-mail: Tom.Coenye{at}UGent.be

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1541-1544, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00999-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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