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Heterologous Production of Albicidin: a Promising Approach to Overproducing and Characterizing This Potent Inhibitor of DNA Gyrase

Centre de Coopération Internationale en Recherche Agronomique pour le Développement, UMR Agro.M-Cirad-Inra BGPI, Campus International de Baillarguet, TA 41/K, 34398 Montpellier Cedex 5, France,¹ Department of Plant Pathology, University of Florida, Gainesville, Florida 32611²

Received 20 November 2006/ Returned for modification 18 December 2006/ Accepted 27 December 2006

The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction.

Published ahead of print on 12 January 2007.

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