AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.00893-06v1
51/4/1556    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aslam, S.
Right arrow Articles by Darouiche, R. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aslam, S.
Right arrow Articles by Darouiche, R. O.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2007, p. 1556-1558, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00893-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Combination of Tigecycline and N-Acetylcysteine Reduces Biofilm-Embedded Bacteria on Vascular Catheters{triangledown}

Saima Aslam,1* Barbara W. Trautner,1,2 Venkat Ramanathan,2,3 and Rabih O. Darouiche1,2*

Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030,1 Medical Service, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030,2 Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 770303

Received 19 July 2006/ Returned for modification 1 December 2006/ Accepted 28 December 2006

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

* Corresponding author. Mailing address: Infectious Disease Section, Room 4B-370, Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030. Phone for Saima Aslam: (713) 791-1414, ext. 5546. Fax: (713) 794-7045. E-mail: saslam{at}bcm.tmc.edu. Phone for Rabih O. Darouiche: (713) 794-8858. Fax: (713) 794-7045. E-mail: rdarouiche{at}aol.com

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1556-1558, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00893-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.