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Antimicrobial Agents and Chemotherapy, April 2007, p. 1556-1558, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00893-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Combination of Tigecycline and N-Acetylcysteine Reduces Biofilm-Embedded Bacteria on Vascular Catheters{triangledown}

Saima Aslam,1* Barbara W. Trautner,1,2 Venkat Ramanathan,2,3 and Rabih O. Darouiche1,2*

Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030,1 Medical Service, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030,2 Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 770303

Received 19 July 2006/ Returned for modification 1 December 2006/ Accepted 28 December 2006

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

* Corresponding author. Mailing address: Infectious Disease Section, Room 4B-370, Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030. Phone for Saima Aslam: (713) 791-1414, ext. 5546. Fax: (713) 794-7045. E-mail: saslam{at}bcm.tmc.edu. Phone for Rabih O. Darouiche: (713) 794-8858. Fax: (713) 794-7045. E-mail: rdarouiche{at}aol.com

{triangledown} Published ahead of print on 12 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1556-1558, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00893-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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