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Antimicrobial Agents and Chemotherapy, April 2007, p. 1559-1562, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00973-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus{triangledown}

Aldona L. Baltch,1,2* William J. Ritz,1,2 Lawrence H. Bopp,1 Phyllis B. Michelsen,1,2 and Raymond P. Smith1,2

Infectious Disease Research Laboratory, Stratton Veterans Affairs Medical Center,1 Albany Medical College, Albany, New York2

Received 4 August 2006/ Returned for modification 24 September 2006/ Accepted 28 January 2007

We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of daptomycin, gentamicin, and rifampin was most effective intracellularly, while daptomycin plus gentamicin and the three-drug combination were most effective extracellularly, completely eliminating viable Staphylococcus aureus.

* Corresponding author. Mailing address: Infectious Disease Section (111D), Stratton VA Medical Center, Albany, NY 12208. Phone: (518) 626-6416. Fax: (518) 626-6564. E-mail: aldona.baltch{at}med.va.gov

{triangledown} Published ahead of print on 5 February 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1559-1562, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.00973-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nguyen, H. A., Denis, O., Vergison, A., Tulkens, P. M., Struelens, M. J., Van Bambeke, F. (2009). Intracellular Activity of Antibiotics in a Model of Human THP-1 Macrophages Infected by a Staphylococcus aureus Small-Colony Variant Strain Isolated from a Cystic Fibrosis Patient: Study of Antibiotic Combinations. Antimicrob. Agents Chemother. 53: 1443-1449 [Abstract] [Full Text]  
  • Baltch, A. L., Ritz, W. J., Bopp, L. H., Michelsen, P., Smith, R. P. (2008). Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, against Extracellular and Intracellular Staphylococcus aureus and Its Stable Small-Colony Variant in Human Monocyte-Derived Macrophages and in Broth. Antimicrob. Agents Chemother. 52: 1829-1833 [Abstract] [Full Text]  


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