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Antimicrobial Agents and Chemotherapy, April 2007, p. 1563-1565, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01326-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Drug Therapy of Experimental Tuberculosis (TB): Improved Outcome by Combining SQ109, a New Diamine Antibiotic, with Existing TB Drugs{triangledown}

Boris V. Nikonenko,1,2* Marina Protopopova,1 Rowena Samala,1 Leo Einck,1 and Carol A. Nacy1

Sequella, Inc., Rockville, Maryland 20850,1 Central Research Institute for Tuberculosis, Moscow 107564, Russia2

Received 24 October 2006/ Returned for modification 27 November 2006/ Accepted 13 January 2007

Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log10 lower in SQ109-containing regimens.

* Corresponding author. Mailing address: Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850. Phone: (301) 762-7776. Fax: (301) 762-7778. E-mail: borisnikonenko{at}sequella.com

{triangledown} Published ahead of print on 22 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1563-1565, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01326-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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