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Antimicrobial Agents and Chemotherapy, April 2007, p. 1566-1569, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01437-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone Resistance in Haemophilus influenzae Is Associated with Hypermutability{triangledown}

María Pérez-Vázquez,1 Federico Román,1 Silvia García-Cobos,1 and José Campos1,2*

Antibiotic Laboratory, Bacteriology Service, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain,1 Consejo Superior de Investigaciones Científicas, Madrid, Spain2

Received 17 November 2006/ Returned for modification 22 December 2006/ Accepted 26 January 2007

Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P = 0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.

* Corresponding author. Mailing address: Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain. Phone: 34 918223650. Fax: 34 915097966. E-mail: jcampos{at}isciii.es

{triangledown} Published ahead of print on 5 February 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1566-1569, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01437-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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