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Antimicrobial Agents and Chemotherapy, April 2007, p. 1566-1569, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01437-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone Resistance in Haemophilus influenzae Is Associated with Hypermutability

Antibiotic Laboratory, Bacteriology Service, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain,¹ Consejo Superior de Investigaciones Científicas, Madrid, Spain²

Received 17 November 2006/ Returned for modification 22 December 2006/ Accepted 26 January 2007

Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P = 0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.

Published ahead of print on 5 February 2007.

This article has been cited by other articles:

• Yokota, S.-i., Ohkoshi, Y., Sato, K., Fujii, N. (2008). Emergence of Fluoroquinolone-Resistant Haemophilus influenzae Strains among Elderly Patients but Not among Children. J. Clin. Microbiol. 46: 361-365 [Abstract] [Full Text]