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Antimicrobial Agents and Chemotherapy, April 2007, p. 1573-1576, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01038-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antifungal Drug Susceptibility Profile of Pichia anomala Isolates from Patients Presenting with Nosocomial Fungemia{triangledown}

Vânia Lúcia Ribeiro da Matta,1* Márcia de Souza Carvalho Melhem,1 Arnaldo Lopes Colombo,2 Maria Luiza Moretti,3 Laura Rodero,4 Gisele Madeira Duboc de Almeida,5 Marilena dos Anjos Martins,1 Silvia Figueiredo Costa,6 Maria Beatriz G. Souza Dias,7 Márcio Nucci,8 and Anna S. Levin6,9

Adolfo Lutz Institute, Secretary of Health, São Paulo State, São Paulo, Brazil,1 Division of Infectious Diseases, Federal University of São Paulo, São Paulo, Brazil,2 Infectious Diseases Division, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, Brazil,3 Facultad de Medicina, Universidad Católica Argentina, Buenos Aires, Argentina,4 Laboratory of Clinical Microbiology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil,5 Hospital Infection Control Department, LIM 54, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil,6 Hospital Sírio Libanês, São Paulo, Brazil,7 Department of Internal Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil,8 Department of Infectious Diseases, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil9

Received 18 August 2006/ Returned for modification 17 October 2006/ Accepted 13 January 2007

In vitro susceptibility of 58 isolates of Pichia anomala to five antifungal drugs using two broth microdilution methods (CLSI and EUCAST) was analyzed. Low susceptibility to itraconazole was observed. Fluconazole, voriconazole, amphotericin B, and caspofungin showed good antifungal activity, although relatively high drug concentrations were necessary to inhibit the isolates.

* Corresponding author. Mailing address: Instituto Adolfo Lutz, Av Dr. Arnaldo 351, 11° andar, São Paulo, São Paulo, Brazil 01246-901. Phone: 55 11 3068 2900. Fax: 55 11 3085 3505. E-mail: mattav{at}usp.br

{triangledown} Published ahead of print on 29 January 2007.

Antimicrobial Agents and Chemotherapy, April 2007, p. 1573-1576, Vol. 51, No. 4
0066-4804/07/$08.00+0     doi:10.1128/AAC.01038-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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