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Antimicrobial Agents and Chemotherapy, May 2007, p. 1830-1834, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01453-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Clonal Spread of mef-Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany{triangledown}

Mark van der Linden, Adnan Al-Lahham,{dagger} Stefan Haupts, and Ralf René Reinert*

Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Aachen, Germany

Received 20 November 2006/ Returned for modification 24 December 2006/ Accepted 16 February 2007

Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.

* Corresponding author. Mailing address: Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstr. 30, Aachen, Germany. Phone: 49 241 8089946. Fax: 49 241 8082483. E-mail: Reinert{at}rwth-aachen.de

{triangledown} Published ahead of print on 26 February 2007.

{dagger} Present address: School of Applied Medical Sciences, German-Jordanian University, Amman, Jordan.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1830-1834, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01453-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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