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Antimicrobial Agents and Chemotherapy, May 2007, p. 1837-1839, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00924-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria{triangledown}

Karen F. Novak,1* William J. Diamond,1 Sreenatha Kirakodu,1 Rebecca Peyyala,1 Kimberly W. Anderson,2 Ronald C. Montelaro,3 and Timothy A. Mietzner3

Center for Oral Health Research, College of Dentistry,1 Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, Kentucky,2 Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania3

Received 26 July 2006/ Returned for modification 6 October 2006/ Accepted 12 February 2007

The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

* Corresponding author. Mailing address: Center for Oral Health Research, 414 Health Sciences Research Building, 1095 VA Drive, University of Kentucky, Lexington, KY 40536-0305. Phone: (859) 323-8705. Fax: (859) 257-6566. E-mail: knova2{at}uky.edu

{triangledown} Published ahead of print on 26 February 2007.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1837-1839, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00924-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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