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Antimicrobial Agents and Chemotherapy, May 2007, p. 1849-1851, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01551-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Isepamicin, Other Aminoglycosides, and Capreomycin against Clinical Isolates of Rapidly Growing Mycobacteria in Taiwan

Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China,¹ Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan, Republic of China,² Rui-Fu-Shi Medical Laboratory, Taichung, Taiwan, Republic of China³

Received 14 December 2006/ Returned for modification 29 December 2006/ Accepted 1 March 2007

The in vitro activities of isepamicin against 117 Mycobacteria abscessus, 48 Mycobacterium fortuitum, and 20 Mycobacterium chelonae isolates were evaluated by a microdilution test. Isepamicin MIC₉₀s were 16 µg/ml for the three species. Isepamicin was as active as amikacin and kanamycin and more active than tobramycin, capreomycin, gentamicin, and streptomycin.

Published ahead of print on 12 March 2007.