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Antimicrobial Agents and Chemotherapy, May 2007, p. 1852-1854, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01544-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth{triangledown}

Yuliya V. Mishina,1 Sanjeev Krishna,2 Richard K. Haynes,3 and John C. Meade1*

Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi,1 Division of Cellular and Molecular Medicine, Centre for Infection, St George's, University of London, Cranmer Terrace, London, United Kingdom,2 Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, People's Republic of China3

Received 11 December 2006/ Returned for modification 10 January 2007/ Accepted 21 February 2007

Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.

* Corresponding author. Mailing address: Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MI 39216. Phone: (601) 984-1914. Fax: (601) 984-1708. E-mail: jmeade{at}microbio.umsmed.edu

{triangledown} Published ahead of print on 5 March 2007.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1852-1854, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01544-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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