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A Candida albicans Petite Mutant Strain with Uncoupled Oxidative Phosphorylation Overexpresses MDR1 and Has Diminished Susceptibility to Fluconazole and Voriconazole

Shaoji Cheng,^1, Cornelius J. Clancy,^1,2, Katherine T. Nguyen,¹ William Clapp,^1,2 and M. Hong Nguyen^1,2*

University of Florida College of Medicine,¹ North Florida/South Georgia Randall Veterans Health System, Gainesville, Florida²

Received 7 February 2007/ Accepted 11 February 2007

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely accounts for the decreased drug susceptibility.

Published ahead of print on 26 February 2007.

S.C. and C.J.C. contributed equally to the manuscript.

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