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Antimicrobial Agents and Chemotherapy, May 2007, p. 1855-1858, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00182-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Candida albicans Petite Mutant Strain with Uncoupled Oxidative Phosphorylation Overexpresses MDR1 and Has Diminished Susceptibility to Fluconazole and Voriconazole{triangledown}

Shaoji Cheng,1,{dagger} Cornelius J. Clancy,1,2,{dagger} Katherine T. Nguyen,1 William Clapp,1,2 and M. Hong Nguyen1,2*

University of Florida College of Medicine,1 North Florida/South Georgia Randall Veterans Health System, Gainesville, Florida2

Received 7 February 2007/ Accepted 11 February 2007

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely accounts for the decreased drug susceptibility.

* Corresponding author. Mailing address: University of Florida College of Medicine, P.O. Box 100277, JHMHC, Gainesville, FL 32610. Phone: (352) 379-4027. Fax: (352) 379-4015. E-mail: nguyemt{at}medicine.ufl.edu

{triangledown} Published ahead of print on 26 February 2007.

{dagger} S.C. and C.J.C. contributed equally to the manuscript.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1855-1858, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00182-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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