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Antimicrobial Agents and Chemotherapy, May 2007, p. 1859-1862, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00426-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Susceptibility of Drug-Resistant Clinical Herpes Simplex Virus Type 1 Strains to Essential Oils of Ginger, Thyme, Hyssop, and Sandalwood{triangledown}

Paul Schnitzler,1* Christine Koch,1,2 and Jürgen Reichling2

Department of Virology, Hygiene Institute,1 Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany2

Received 5 April 2006/ Returned for modification 8 June 2006/ Accepted 2 March 2007

Acyclovir-resistant clinical isolates of herpes simplex virus type 1 (HSV-1) were analyzed in vitro for their susceptibilities to essential oils of ginger, thyme, hyssop, and sandalwood. All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 clinical isolates and reduced plaque formation significantly.

* Corresponding author. Mailing address: Hygiene Institute, Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. Phone: 49-6221-56 50 16. Fax: 49-6221-56 50 03. E-mail: Paul_Schnitzler{at}med.uni-heidelberg.de

{triangledown} Published ahead of print on 12 March 2007.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1859-1862, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00426-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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