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Antimicrobial Agents and Chemotherapy, May 2007, p. 1863-1864, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01273-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Two New dfr Genes in Trimethoprim-Resistant Integron-Negative Escherichia coli Isolates{triangledown}

M. Grape,1 L. Sundström,2 and G. Kronvall1*

Department of Microbiology, Tumor and Cell Biology (MTC), Clinical Microbiology, Karolinska Institute, Stockholm,1 Department of Medical Biochemistry and Microbiology (IMBIM), Uppsala University, Uppsala, Sweden2

Received 11 October 2006/ Returned for modification 21 November 2006/ Accepted 7 February 2007

Two Escherichia coli isolates resistant to trimethoprim but negative for integrons carried two new resistance genes, dfrA24 and dfrA26, remotely similar to one another and to the cassette-independent genes dfrA8 and dfrA9. The dfrA24 gene was not associated with known mobile elements, while dfrA26 was associated with the CR1 common region.

* Corresponding author. Mailing address: MTC, Clinical Microbiology, Karolinska Institute, Karolinska Hospital L2:02, Stockholm SE-171 76, Sweden. Phone: 46 8 517 749 10. Fax: 46 8 30 80 99. E-mail: goran.kronvall{at}ki.se

{triangledown} Published ahead of print on 16 February 2007.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1863-1864, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01273-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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