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Antimicrobial Agents and Chemotherapy, May 2007, p. 1865-1868, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01341-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Tetracycline Resistance in Group A Streptococci: Emergence on a Global Scale and Influence on Multiple-Drug Resistance ^,

Vanessa Ayer, Wezenet Tewodros, Anand Manoharan, Sini Skariah, Feng Luo, and Debra E. Bessen^*

Department of Microbiology and Immunology, New York Medical College, Valhalla, New York

Received 26 October 2006/ Returned for modification 4 January 2007/ Accepted 8 February 2007

A global sample of group A streptococci (GAS) revealed 80 separate acquisitions of tetracycline resistance. Of 244 clones, 38 and 25% displayed resistance to tetracycline and erythromycin, respectively; a relatively high proportion (15%) were resistant to both classes of drugs. tet(M) displayed a highly significant association with erm(B).

Published ahead of print on 16 February 2007.

Supplemental material for this article may be found at http://aac.asm.org/.

Present address: Spartan Health Science University School of Medicine, Vieux Fort, St. Lucia, West Indies.

Present address: Department of Medicine Unit I and Infectious Diseases, Christian Medical College, Vellore, India.