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Antimicrobial Agents and Chemotherapy, May 2007, p. 1876-1878, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.00067-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase

Merck Research Laboratories, Rahway,¹ Public Health Research Institute, New Jersey Medical School—UMDNJ, Newark, New Jersey,² Fred Hutchinson Cancer Research Center, Seattle, Washington³

Received 16 January 2007/ Returned for modification 28 January 2007/ Accepted 12 February 2007

A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.

Published ahead of print on 26 February 2007.

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