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Antimicrobial Agents and Chemotherapy, May 2007, p. 1882-1884, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01525-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Candida albicans and Candida dubliniensis Respond Differently to Echinocandin Antifungal Agents In Vitro{triangledown}

Mette D. Jacobsen, Julie A. Whyte, and Frank C. Odds*

Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom

Received 5 December 2006/ Returned for modification 10 January 2007/ Accepted 11 February 2007

Candida dubliniensis isolates tested for susceptibility to anidulafungin, caspofungin, and micafungin commonly showed artifactual regrowth and/or trailing effects with MIC tests done under conditions involving a high initial yeast concentration. The artifacts were less common with Candida albicans and seldom seen for either species under Clinical and Laboratory Standards Institute method M27-A test conditions.

* Corresponding author. Mailing address: Institute of Medical Sciences, Aberdeen AB25 2ZD, United Kingdom. Phone and fax: 44 1224 555828. E-mail: f.odds{at}abdn.ac.uk

{triangledown} Published ahead of print on 16 February 2007.

Antimicrobial Agents and Chemotherapy, May 2007, p. 1882-1884, Vol. 51, No. 5
0066-4804/07/$08.00+0     doi:10.1128/AAC.01525-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Marine, M., Pastor, F. J., Sahand, I. H., Ponton, J., Quindos, G., Guarro, J. (2009). Paradoxical Growth of Candida dubliniensis Does Not Preclude In Vivo Response to Echinocandin Therapy. Antimicrob. Agents Chemother. 53: 5297-5299 [Abstract] [Full Text]  
  • Varga, I., Soczo, G., Kardos, G., Majoros, L. (2008). Time-kill studies investigating the killing activity of caspofungin against Candida dubliniensis: comparing RPMI-1640 and antibiotic medium 3. J Antimicrob Chemother 62: 149-152 [Abstract] [Full Text]  


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