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Antimicrobial Agents and Chemotherapy, June 2007, p. 2195-2197, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01587-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Determination of the Genetic Support for tet(W) in Oral Bacteria{triangledown}

A. Villedieu,1 A. P. Roberts,1 E. Allan,1 H. Hussain,1 R. McNab,2 D. A. Spratt,1 M. Wilson,1 and P. Mullany1*

Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, University College London, London WC1X 8LD, United Kingdom,1 GlaxoSmithKline Oral Healthcare, Weybridge, United Kingdom2

Received 20 December 2006/ Returned for modification 26 January 2007/ Accepted 13 March 2007

The DNA sequence flanking a tet(W) gene in an oral Rothia sp. was determined. The gene was linked to two different transposases, and these were flanked by two almost identical mef (macrolide efflux) genes. This structure was found in 4 out of 20 tet(W)-containing oral bacteria investigated.

* Corresponding author. Mailing address: Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, University College London, London WC1X 8LD, United Kingdom. Phone: 44 20 7915 1223. Fax: 44 20 7915 1127. E-mail: p.mullany{at}eastman.ucl.ac.uk

{triangledown} Published ahead of print on 19 March 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2195-2197, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01587-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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