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Antimicrobial Agents and Chemotherapy, June 2007, p. 2198-2200, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00506-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Lysostaphin in Treatment of Neonatal Staphylococcus aureus Infection{triangledown}

Okunola Oluola,{dagger} Lingkun Kong, Mindy Fein, and Leonard E. Weisman*

Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, 6621 Fannin St., FC830.17, Houston, Texas 77030-2799

Received 24 April 2006/ Returned for modification 9 August 2006/ Accepted 26 March 2007

This study describes lysostaphin's effect against methicillin-sensitive Staphylococcus aureus in suckling rats. Standard techniques determined minimal inhibitory and bactericidal concentrations, pharmacokinetics, and efficacy. The numbers of surviving rats after vancomycin, oxacillin, and lysostaphin treatment were comparable and were different from that of controls (P < 0.00001). Lysostaphin appears effective in the treatment of neonatal S. aureus infection.

* Corresponding author. Mailing address: Baylor College of Medicine and Perinatal Center, Texas Children's Hospital, 6621 Fannin St., FC830.17, Houston, TX 77030-2799. Phone: (832) 824-1387. Fax: (832) 825-2799. E-mail: lweisman{at}bcm.edu

{triangledown} Published ahead of print on 9 April 2007.

{dagger} Present address: Division of Neonatology, Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2198-2200, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00506-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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