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Antimicrobial Agents and Chemotherapy, June 2007, p. 2201-2204, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01389-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Preservation of Integron Types among Enterobacteriaceae Producing Extended-Spectrum ß-Lactamases in a Spanish Hospital over a 15-Year Period (1988 to 2003){triangledown}

Elisabete Machado,1,3,4 Joana Ferreira,1,3 Ângela Novais,1 Luísa Peixe,3 Rafael Cantón,1,2 Fernando Baquero,1,2 and Teresa M. Coque1,2*

Hospital Universitario Ramón y Cajal, IMSALUD, Madrid, Spain,1 Unidad de Resistencia a Antibióticos y Virulencia Bacteriana Asociada al Consejo Superior de Investigaciones Científicas, Madrid, Spain,2 REQUIMTE, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal,3 Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal4

Received 6 November 2006/ Returned for modification 27 December 2006/ Accepted 22 March 2007

The variable presence of integrons among extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae species (0 to 66%) is described. Association between blaESBL and integrons occurred when these are linked to specific ESBL-type genes (In60 bearing ISCR1 and blaCTX-M-9) or when ESBL genes were superimposed onto selected plasmids carrying integrons. Some integrons were identical to those found during decades worldwide, illustrating the preservation of the genetic elements carrying them.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Universitario Ramón y Cajal. Carretera de Colmenar, km. 9.1. Madrid 28034, Spain. Phone: 34-913368330. Fax: 34-913368809. E-mail: mcoque.hrc{at}salud.madrid.org

{triangledown} Published ahead of print on 2 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2201-2204, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01389-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vinue, L., Saenz, Y., Somalo, S., Escudero, E., Moreno, M. A., Ruiz-Larrea, F., Torres, C. (2008). Prevalence and diversity of integrons and associated resistance genes in faecal Escherichia coli isolates of healthy humans in Spain. J Antimicrob Chemother 62: 934-937 [Abstract] [Full Text]  
  • Machado, E., Coque, T. M., Canton, R., Sousa, J. C., Peixe, L. (2008). Antibiotic resistance integrons and extended-spectrum {beta}-lactamases among Enterobacteriaceae isolates recovered from chickens and swine in Portugal. J Antimicrob Chemother 62: 296-302 [Abstract] [Full Text]  


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