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Antimicrobial Agents and Chemotherapy, June 2007, p. 2215-2218, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01368-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Broad-Spectrum Antiviral Activity of Small Interfering RNA Targeting the Conserved RNA Termini of Lassa Virus{triangledown}

Stefanie Müller and Stephan Günther*

Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany

Received 1 November 2006/ Returned for modification 22 December 2006/ Accepted 8 March 2007

Small interfering RNAs targeting the conserved RNA termini upstream of NP and L gene were found to reduce reporter gene expression from Lassa virus replicon and Lassa virus mRNA expression construct and to inhibit replication of different Lassa virus strains, lymphocytic choriomeningitis virus, and Mopeia virus in cell culture.

* Corresponding author. Mailing address: Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany. Phone: 49 40 42818 421. Fax: 49 40 42818 378. E-mail: guenther{at}bni.uni-hamburg.de

{triangledown} Published ahead of print on 19 March 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2215-2218, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01368-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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