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In Vitro Activities of Miltefosine and Two Novel Antifungal Biscationic Salts against a Panel of 77 Dermatophytes

Research Laboratory for Infectious Skin Diseases, Department of Dermatology, Wuhan First Hospital, Wuhan, People's Republic of China,¹ Centre for Infectious Diseases and Microbiology and Centre for Clinical Research Excellence in Infections, Bioethics and Haematological Malignancies,² Centre for Infectious Diseases and Microbiology Laboratory Services, University of Sydney at Westmead, Westmead,³ School of Chemistry, University of Sydney, Sydney, Australia⁴

Received 5 November 2006/ Returned for modification 11 January 2007/ Accepted 12 March 2007

The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 µg/ml, respectively. MI was more active than ITC (P < 0.001).

Published ahead of print on 19 March 2007.