This Article Full Text Full Text (PDF) Other Versions of this Article: AAC.01097-06v1 51/6/2226    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Balaban, N. Articles by Scalise, G. Search for Related Content PubMed PubMed Citation Articles by Balaban, N. Articles by Scalise, G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2007, p. 2226-2229, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01097-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Treatment of Staphylococcus aureus Biofilm Infection by the Quorum-Sensing Inhibitor RIP

Department of Biomedical Sciences, Division of Infectious Diseases, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536,¹ Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy,² Department of General Surgery, INRCA, IRRCS, University of Ancona, Ancona, Italy,³ Centegen Inc. Baltimore, Maryland 21208⁴

Received 30 August 2006/ Returned for modification 25 January 2007/ Accepted 7 March 2007

The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.

Published ahead of print on 19 March 2007.

This article has been cited by other articles:

• Kiran, M. D., Adikesavan, N. V., Cirioni, O., Giacometti, A., Silvestri, C., Scalise, G., Ghiselli, R., Saba, V., Orlando, F., Shoham, M., Balaban, N. (2008). Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening. Mol. Pharmacol. 73: 1578-1586 [Abstract] [Full Text]  
• Cirioni, O., Ghiselli, R., Minardi, D., Orlando, F., Mocchegiani, F., Silvestri, C., Muzzonigro, G., Saba, V., Scalise, G., Balaban, N., Giacometti, A. (2007). RNAIII-Inhibiting Peptide Affects Biofilm Formation in a Rat Model of Staphylococcal Ureteral Stent Infection. Antimicrob. Agents Chemother. 51: 4518-4520 [Abstract] [Full Text]  
• Tsang, L. H., Daily, S. T., Weiss, E. C., Smeltzer, M. S. (2007). Mutation of traP in Staphylococcus aureus Has No Impact on Expression of agr or Biofilm Formation. Infect. Immun. 75: 4528-4533 [Abstract] [Full Text]  
• Shaw, L. N., Jonsson, I.-M., Singh, V. K., Tarkowski, A., Stewart, G. C. (2007). Inactivation of traP Has No Effect on the Agr Quorum-Sensing System or Virulence of Staphylococcus aureus. Infect. Immun. 75: 4519-4527 [Abstract] [Full Text]