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Antimicrobial Agents and Chemotherapy, June 2007, p. 2226-2229, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01097-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Treatment of Staphylococcus aureus Biofilm Infection by the Quorum-Sensing Inhibitor RIP{triangledown}

Naomi Balaban,1* Oscar Cirioni,2 Andrea Giacometti,2 Roberto Ghiselli,3 Joel B. Braunstein,4 Carmela Silvestri,2 Federico Mocchegiani,3 Vittorio Saba,3 and Giorgio Scalise2

Department of Biomedical Sciences, Division of Infectious Diseases, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536,1 Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy,2 Department of General Surgery, INRCA, IRRCS, University of Ancona, Ancona, Italy,3 Centegen Inc. Baltimore, Maryland 212084

Received 30 August 2006/ Returned for modification 25 January 2007/ Accepted 7 March 2007

The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.

* Corresponding author. Mailing address: Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536. Phone: (508) 887-4256. Fax: (508) 839-7911. E-mail: naomi.balaban{at}tufts.edu

{triangledown} Published ahead of print on 19 March 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2226-2229, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01097-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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