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Antimicrobial Agents and Chemotherapy, June 2007, p. 2236-2239, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01444-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mutant Prevention Concentrations of Fluoroquinolones for Enterobacteriaceae Expressing the Plasmid-Carried Quinolone Resistance Determinant qnrA1{triangledown}

J. M. Rodríguez-Martínez,1* C. Velasco,1 I. García,1 M. E. Cano,3 L. Martínez-Martínez,3 and A. Pascual1,2

Department of Microbiology, University of Seville, Seville,1 Service of Microbiology, University Hospital Virgen Macarena, Seville,2 Service of Microbiology, University Hospital Marqués de Valdecilla, Santander, Spain3

Received 17 November 2006/ Returned for modification 18 December 2006/ Accepted 19 March 2007

The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

* Corresponding author. Mailing address: Department of Microbiology, University of Seville, Sanchez Pizjuan s/n, Seville 41009, Spain. Phone: 34 954 55 28 63. Fax: 34 954 37 74 13. E-mail: jmrodriguez{at}us.es

{triangledown} Published ahead of print on 2 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2236-2239, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01444-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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