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Antimicrobial Agents and Chemotherapy, June 2007, p. 2244-2246, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00229-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mutations in 16S rRNA and Ribosomal Protein S5 Associated with High-Level Spectinomycin Resistance in Pasteurella multocida{triangledown}

Corinna Kehrenberg and Stefan Schwarz*

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany

Received 15 February 2007/ Returned for modification 4 March 2007/ Accepted 12 March 2007

Pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a C1192G transversion in the 16S rRNA of all six or five of the six rRNA operons and/or two different types of 3-bp deletions in the rpsE gene that codes for the ribosomal protein S5.

* Corresponding author. Mailing address: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany. Phone: 49-5034-871-241. Fax: 49-5034-871-246. E-mail: stefan.schwarz{at}fal.de

{triangledown} Published ahead of print on 19 March 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2244-2246, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00229-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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