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Antimicrobial Agents and Chemotherapy, June 2007, p. 2247-2248, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00241-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Transient Loss of High-Level Mupirocin Resistance in Staphylococcus aureus Due to MupA Polymorphism{triangledown}

Daniel G. Driscoll, Casey L. Young, and Urs A. Ochsner*

Replidyne, Inc., Louisville, Colorado 80027

Received 16 February 2007/ Returned for modification 18 March 2007/ Accepted 5 April 2007

Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed in Staphylococcus aureus, although the isolate gave a PCR-positive test result for mupA. Sequencing of the mupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10–6), indicating the transient nature of MupA polymorphism.

* Corresponding author. Mailing address: Replidyne, Inc., Dept. Microbiology, 1450 Infinite Dr., Louisville, CO 80027. Phone: (303) 996-5532. Fax: (303) 996-5599. E-mail: uochsner{at}replidyne.com

{triangledown} Published ahead of print on 16 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2247-2248, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00241-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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