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Antimicrobial Agents and Chemotherapy, June 2007, p. 2249-2252, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01000-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [3H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall{triangledown}

A. Stucki,1 M. Cottagnoud,2 V. Winkelmann,3 T. Schaffner,3 and P. Cottagnoud1*

Department of Internal Medicine, Inselspital, Bern, Switzerland,1 Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland,2 Institute for Pathology, Inselspital, Bern, Switzerland3

Received 10 August 2006/ Returned for modification 25 January 2007/ Accepted 8 March 2007

Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [3H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland. Phone: 41-31-632-34-72. Fax: 41-31-632-38-47. E-mail: pcottagn{at}insel.ch

{triangledown} Published ahead of print on 19 March 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2249-2252, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01000-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Egermann, U., Stanga, Z., Ramin, A., Acosta, F., Stucki, A., Gerber, P., Cottagnoud, M., Cottagnoud, P. (2009). Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone. Antimicrob. Agents Chemother. 53: 3030-3033 [Abstract] [Full Text]  
  • Chiavolini, D., Pozzi, G., Ricci, S. (2008). Animal Models of Streptococcus pneumoniae Disease. Clin. Microbiol. Rev. 21: 666-685 [Abstract] [Full Text]  
  • Grandgirard, D., Schurch, C., Cottagnoud, P., Leib, S. L. (2007). Prevention of Brain Injury by the Nonbacteriolytic Antibiotic Daptomycin in Experimental Pneumococcal Meningitis. Antimicrob. Agents Chemother. 51: 2173-2178 [Abstract] [Full Text]  


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