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Antimicrobial Agents and Chemotherapy, June 2007, p. 2249-2252, Vol. 51, No. 6
0066-4804/07/$08.00+0 doi:10.1128/AAC.01000-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Department of Internal Medicine, Inselspital, Bern, Switzerland,1 Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland,2 Institute for Pathology, Inselspital, Bern, Switzerland3
Received 10 August 2006/ Returned for modification 25 January 2007/ Accepted 8 March 2007
Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [3H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.
Published ahead of print on 19 March 2007.
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