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Antimicrobial Agents and Chemotherapy, June 2007, p. 2253-2256, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01536-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Serum Differentially Alters the Antifungal Properties of Echinocandin Drugs{triangledown}

Padmaja Paderu, Guillermo Garcia-Effron, Sergey Balashov, Guillaume Delmas, Steven Park, and David S. Perlin*

Public Health Research Institute, Newark, New Jersey 07103

Received 8 December 2006/ Returned for modification 10 January 2007/ Accepted 23 March 2007

Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.

* Corresponding author. Mailing address: Public Health Research Institute, 225 Warren St., Newark, NJ 07103. Phone: (973) 854-3200. Fax: (914) 854-3101. E-mail: perlin{at}phri.org

{triangledown} Published ahead of print on 9 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2253-2256, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01536-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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