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Antimicrobial Agents and Chemotherapy, June 2007, p. 2265-2267, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01479-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Effects of Piperaquine, Chloroquine, and Amodiaquine on Drug Uptake and of These in Combination with Dihydroartemisinin against Drug-Sensitive and -Resistant Plasmodium falciparum Strains{triangledown}

Quinton L. Fivelman,* Ipemida S. Adagu, and David C. Warhurst

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom

Received 24 November 2006/ Returned for modification 15 February 2007/ Accepted 19 March 2007

Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were indifferent tending toward antagonism. Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed.

* Corresponding author. Mailing address: Third Floor ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Phone: 44 020 7927 2416. Fax: 44 020 7636 8739. E-mail: quinton.fivelman{at}lshtm.ac.uk

{triangledown} Published ahead of print on 2 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2265-2267, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01479-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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