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Antimicrobial Agents and Chemotherapy, June 2007, p. 2265-2267, Vol. 51, No. 6
0066-4804/07/$08.00+0 doi:10.1128/AAC.01479-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Received 24 November 2006/ Returned for modification 15 February 2007/ Accepted 19 March 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were indifferent tending toward antagonism. Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed.
Published ahead of print on 2 April 2007.
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