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Antimicrobial Agents and Chemotherapy, June 2007, p. 2268-2273, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01422-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains{triangledown}

Ilya Lebeau,1 Graciela Andrei,1 Marcela Krecmerová,2 Erik De Clercq,1 Antonin Holy,2 and Robert Snoeck1*

Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium,1 Gilead Sciences and IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Centre for New Antivirals and Antineoplastics (IOCB), Flemingovo nám. 2, CZ-166 10, Prague 6, Czech Republic2

Received 14 November 2006/ Returned for modification 1 February 2007/ Accepted 28 March 2007

Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.

* Corresponding author. Mailing address: Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium. Phone: 32 16 33 73 72. Fax: 32 16 33 73 40. E-mail: robert.snoeck{at}rega.kuleuven.be

{triangledown} Published ahead of print on 9 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2268-2273, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.01422-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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