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Antimicrobial Agents and Chemotherapy, June 2007, p. 2274-2277, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00917-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Prophylactic Effect of Dietary Seaweed Fucoidan against Enteral Prion Infection{triangledown}

Katsumi Doh-ura,1* Tomoko Kuge,2 Miyuki Uomoto,1 Keiko Nishizawa,1 Yuri Kawasaki,1 and Masahiko Iha3

Department of Prion Research, Tohoku University Graduate School of Medicine, Sendai, Japan,1 Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan,2 South Product Ltd., Okinawa, Japan3

Received 25 July 2006/ Returned for modification 25 August 2006/ Accepted 28 March 2007

Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

* Corresponding author. Mailing address: Department of Prion Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan. Phone: 81-22-717-8232. Fax: 81-22-717-7656. E-mail: doh-ura{at}mail.tains.tohoku.ac.jp

{triangledown} Published ahead of print on 16 April 2007.

Antimicrobial Agents and Chemotherapy, June 2007, p. 2274-2277, Vol. 51, No. 6
0066-4804/07/$08.00+0     doi:10.1128/AAC.00917-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kawasaki, Y., Kawagoe, K., Chen, C.-j., Teruya, K., Sakasegawa, Y., Doh-ura, K. (2007). Orally Administered Amyloidophilic Compound Is Effective in Prolonging the Incubation Periods of Animals Cerebrally Infected with Prion Diseases in a Prion Strain-Dependent Manner. J. Virol. 81: 12889-12898 [Abstract] [Full Text]  


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